Immunotherapy is helping cancer patients, including those with melanoma, to more successfully fight their diseases. However, a new study released in this month’s Cancer Discovery highlights the fact that a more personalized approach could be even more successful. Brief background… immunotherapy works by activating the body’s T cells to find and destroy cancer cells. Obviously, this only works if the T… Read more »
Immunotherapy has been featured a lot on this blog because of the potential to dramatically improve the survival rates of cancer patients, including those struck by melanoma. Obviously, I’m not the only one excited about the progress made in this field. This year’s Nobel Prize in medicine was awarded to two immunology researchers – Dr. James Allison of the MD… Read more »
So in the last post, I talked about checkpoint blockade immunotherapy and the results it had on prolonging survival rates for those with brain metastases. In the post, I referenced a protein called PD-1, which is found on T cells and acts as a brake on the immune response. Using immune checkpoint inhibitor drugs releases that brake and allows the… Read more »
As I have mentioned a few times in this blog, melanoma has a disconcerting tendency to spread to the lungs, liver, and brain when it enters into the metastasizing stages. And brain tumors like that are pretty darn hard to treat. Most of the current treatments don’t really provide much benefit to patients. And once melanoma metastasizes, only about half… Read more »
My previous post talked about the history of using the immune T-cells in the fight against cancer. I’m picking up the thread of the story where the human experiments began… A small pharmaceutical company approached by researcher Jim Allison, Medarex, decided to begin human trials using patients diagnosed with malignant melanoma. Melanoma sometimes responds to immunotherapy treatment. The first experiments… Read more »
Disclaimer: I’m a science nerd. I love the compilations like the Best American Science and Nature Writing. I got the 2013 edition out of the library and there was an article, originally published in The New Yorker, entitled The T-Cell Army. The article discussed the history of Dr. William Coley, a surgeon in 1890s New York City who lost a… Read more »